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The MultiBac Protein Complex Production Platform at the EMBL
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Biologically active LIL proteins built with minimal chemical diversity

Erin N Heim1, Jez L Marston1, Ross S Federman2

  • 1Department of Genetics, Yale School of Medicine, New Haven, CT 06520-8005;

Proceedings of the National Academy of Sciences of the United States of America
|August 12, 2015
PubMed
Summary

Researchers created simple, artificial transmembrane proteins using only two amino acids, leucine and isoleucine. These minimal proteins activate cell receptors, demonstrating minimal chemical diversity for specific biological activity.

Keywords:
E5 proteinPDGF receptoroncogenesynthetic biologytraptamer

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