Related Experiment Video

Updated: Apr 5, 2026

Ovine Lumbar Intervertebral Disc Degeneration Model Utilizing a Lateral Retroperitoneal Drill Bit Injury
07:25

Ovine Lumbar Intervertebral Disc Degeneration Model Utilizing a Lateral Retroperitoneal Drill Bit Injury

Published on: May 25, 2017

12.3K

Association between TRAIL gene polymorphisms and the susceptibility and severity of lumbar disc degeneration

Heng Du1, Bin Bai1, Yusheng Qiu1

  • 1Department of Orthopedics, The First Affiliated Hospital of Xi'an Jiaotong University Xi'an 710061, Shaanxi, China.

International Journal of Clinical and Experimental Pathology
|August 12, 2015
PubMed

Insights

Tumor necrosis factor related apoptosis-inducing ligand (TRAIL) gene polymorphisms at positions 1525 and 1595 are linked to lumbar disc degeneration (LDD) susceptibility and severity in the Chinese Han population. These TRAIL gene variations may influence LDD development and progression.

Area of Science:

  • Genetics
  • Orthopedics
  • Molecular Biology

Background:

  • Lumbar disc degeneration (LDD) is a prevalent condition with complex etiologies.
  • Genetic factors, including single-nucleotide polymorphisms (SNPs), are increasingly recognized as contributors to LDD.
  • The tumor necrosis factor related apoptosis-inducing ligand (TRAIL) gene plays a role in apoptosis and inflammation, pathways relevant to LDD pathogenesis.

Purpose of the Study:

  • To investigate the association between specific TRAIL gene polymorphisms and the susceptibility to LDD.
  • To explore the relationship between these TRAIL gene variants and the severity of LDD in the Chinese Han population.

Main Methods:

  • Genotyping of four TRAIL gene single-nucleotide polymorphisms (SNPs) in the 3' untranslated region (3'UTR): 1289 C/A, 1525 G/A, 1588 G/A, and 1595 C/T.
  • Utilized polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis for SNP genotyping.
  • Compared genotype and allele frequencies between 153 LDD patients and 131 healthy controls.

Main Results:

  • No significant differences in genotype or allele frequencies for TRAIL 1289 C/A and 1588 G/A between patients and controls.
  • Significant association found between TRAIL 1525 G/A and 1595 C/T polymorphisms and LDD susceptibility.
  • Higher frequencies of TRAIL 1525 GG/1595 CC genotypes and 1525 G/1595 C alleles in LDD patients.
  • TRAIL 1525 AA/1595 TT genotypes and 1525 A/1595 T alleles were associated with a lower frequency of high-grade disc degeneration.

Conclusions:

  • TRAIL gene polymorphisms at positions 1525 and 1595 are significantly associated with LDD susceptibility in the Chinese Han population.
  • These specific TRAIL polymorphisms are also linked to the severity of lumbar disc degeneration, influencing the grade of degeneration.
Abstract

Keywords:
Tumor necrosis factor related apoptosis-inducing ligandlumbar disc degenerationpolymorphismseveritysusceptibility

More Related Videos

Operational and Intervention Effects of Targeted Tuina in Lumbar Intervertebral Disc Degeneration Model Rabbits06:03

Operational and Intervention Effects of Targeted Tuina in Lumbar Intervertebral Disc Degeneration Model Rabbits

Published on: July 21, 2023

1.1K

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
16.7K
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
114