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Myxoid dermatofibroma on a great toe: a case report
Ahrim Moon1, Nara Yoon2, Hyun-Soo Kim3
1Department of Pathology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine Bucheon-si, Gyounggi-do, Republic of Korea.
International Journal of Clinical and Experimental Pathology
|August 12, 2015
Summary
This case report details a rare myxoid dermatofibroma on a great toe. Accurate histopathological diagnosis is crucial for differentiating this benign tumor from other myxoid soft tissue neoplasms.
Area of Science:
- Dermatopathology
- Oncology
- Histopathology
Background:
- Dermatofibroma is a common benign fibrohistiocytic tumor with diverse clinicopathological presentations.
- Myxoid dermatofibroma, a variant, is defined by significant stromal mucin deposition.
- Distinguishing myxoid dermatofibroma from other myxoid neoplasms is essential for accurate patient management.
Observation:
- A case of a slowly growing myxoid dermatofibroma on a great toe over two years is presented.
- Histopathology revealed a dermal tumor with oval to spindle-shaped cells in a myxoid stroma, lacking atypia or mitoses.
- Peripheral areas showed classic dermatofibroma features like storiform pattern and dense collagen.
Findings:
- Immunohistochemistry demonstrated tumor cell positivity for CD68 and CD99, and negativity for CD34 and S-100.
- Differential diagnoses included superficial acral fibromyxoma, cellular digital fibroma, and myxoid dermatofibrosarcoma protuberans.
- Immunohistochemical markers aid in differentiating these entities.
Implications:
- This case underscores the diagnostic challenges in interpreting myxoid dermatofibroma.
- Pathologists must consider myxoid dermatofibroma in the differential diagnosis of acral myxoid lesions.
- Accurate histopathological and immunohistochemical evaluation is key for correct diagnosis and treatment planning.
