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Focal Segmental Glomerulosclerosis Followed by Acute Hepatitis A Infection: Case Report
Min-Woo An1, Jeong-Ju Yoo1, Jin Kuk Kim2
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University School of Medicine, Bucheon 14584, Republic of Korea.
Acute hepatitis A virus (HAV) infection, though rare, can cause nephrotic syndrome, specifically focal segmental glomerulosclerosis (FSGS). Prompt recognition and treatment are crucial for persistent symptoms like proteinuria.
Area of Science:
- Nephrology
- Hepatology
- Virology
Background:
- Chronic viral hepatitis (B, C) commonly causes nephropathies.
- Acute hepatitis A virus (HAV) infection is typically not associated with kidney disease.
Observation:
- A 43-year-old male with acute HAV infection developed persistent nephrotic syndrome (proteinuria, hypoalbuminemia, edema).
- Renal biopsy revealed focal segmental glomerulosclerosis (FSGS).
Findings:
- Acute HAV infection can manifest as FSGS, a form of nephrotic syndrome.
- Prednisolone treatment improved the patient's nephrotic symptoms.
Implications:
- Acute HAV infection should be considered in cases of new-onset nephrotic syndrome.
- Persistent proteinuria or hypoalbuminemia in HAV patients warrants nephrology evaluation.
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