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Updated: Apr 5, 2026
Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
Published on: May 21, 2013
Fresh osteochondral allografts in the knee: only a salvage procedure?
Alberto Gobbi1, Celeste Scotti1, John G Lane1
11 Orthopaedic Arthroscopic Surgery International (O.A.S.I.) Bioresearch Foundation, Gobbi Onlus, Via GA Amadeo 24, 20133 Milan, Italy ; 2 IRCCS Istituto Ortopedico Galeazzi, Via R. Galeazzi 4, 20161 Milan, Italy ; 3 Departments of Bioengineering, Orthopedic Surgery, and Radiology, University of California, San Diego, La Jolla, California, USA ; 4 Sanford Consortium for Regenerative Medicine, La Jolla, California, USA ; 5 Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.
Abstract:
The role of fresh allogeneic osteochondral allograft transplantation (OCA) in the cartilage repair algorithm has been long debated and this procedure is primarily considered as a salvage procedure, to be used when other, simple, techniques have failed. Gracitelli et al. in a retrospective comparison of patients who received OCA as primary treatment or as a salvage procedure, demonstrates that the outcome of this procedure is minimally influenced by a previous failed treatment and that OCA represents an effective solution for both primary and revision surgery of chondral and osteochondral lesions of the knee. In particular, optimal indications for OCA seem to be revision of previously failed bone marrow stimulation techniques with an impaired subchondral bone plate and primary treatment of large osteochondral defects.
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