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Related Experiment Videos

Quantitative evaluation of recurrent meningiomas.

M Scarpelli1, R Montironi, S Sisti

  • 1Department of Pathology, University of Ancona, Italy.

Pathology, Research and Practice
|November 1, 1989
PubMed
Summary

Meningioma recurrence is predicted by mitotic count and nucleolar organizer regions. Recurrent tumors show altered DNA content distribution and increased nucleolar organizer regions compared to non-recurrent cases.

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Area of Science:

  • Neuro-oncology
  • Pathology
  • Genetics

Background:

  • Meningiomas are primary tumors of the meninges.
  • Predicting meningioma recurrence is crucial for patient management.
  • Histological and molecular markers are investigated for prognostic value.

Purpose of the Study:

  • To identify predictive markers for meningioma recurrence.
  • To compare karyometric and DNA content between recurrent and non-recurrent meningiomas.

Main Methods:

  • Comparative analysis of clinical, histological, and karyometric parameters.
  • Nuclear DNA content and nucleolar organizer regions (NORs) assessment.
  • 10-year follow-up for recurrence in 19 meningioma cases.

Main Results:

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  • Recurrent meningiomas showed higher mitotic figures and visible nucleoli.
  • Significant differences in nuclear DNA ploidy distribution observed.
  • Increased 2c-4c and 4c DNA components in recurrent tumors.
  • Higher number of positively stained NORs in recurrent tumors.

Conclusions:

  • Mitotic count and NORs are significant predictors of meningioma recurrence.
  • Nuclear DNA content alterations and NORs reflect tumor aggressiveness.
  • These markers can aid in risk stratification for meningioma patients.