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Related Concept Videos

Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Papillary Dermis01:11

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein...
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Related Experiment Video

Updated: Apr 5, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
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Pleomorphic dermal sarcoma: a more aggressive neoplasm than previously estimated.

Juan C Tardío1, Fernando Pinedo2, José A Aramburu3

  • 1Department of Pathology, Hospital Universitario de Fuenlabrada, Madrid, Spain.

Journal of Cutaneous Pathology
|August 13, 2015
PubMed
Summary
This summary is machine-generated.

Pleomorphic dermal sarcoma (PDS) may be more aggressive than previously thought. This rare skin cancer showed a 20% rate of recurrence and metastasis in a study of 18 patients.

Keywords:
atypical fibroxanthomaimmunohistochemistrypleomorphic dermal sarcomasarcomaskin

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Area of Science:

  • Dermatopathology
  • Surgical Oncology
  • Oncology

Background:

  • Pleomorphic dermal sarcoma (PDS) is a rare skin neoplasm.
  • It shares features with atypical fibroxanthoma but includes necrosis and invasion.
  • Its metastatic risk and prognosis are uncertain due to rarity and varied diagnostic criteria.

Purpose of the Study:

  • To investigate the clinicopathological features and outcomes of Pleomorphic Dermal Sarcoma.
  • To better understand the aggressive potential of PDS.

Main Methods:

  • Retrospective study of 18 Pleomorphic Dermal Sarcoma cases.
  • Analysis of histopathological features, including cell morphology, mitotic activity, and invasion.
  • Review of patient follow-up data for recurrence and metastasis.

Main Results:

  • PDS lesions occurred on the head in elderly patients, presenting as tumors or plaques.
  • Histopathology revealed spindle cells with pleomorphic epithelioid and giant multinucleated cells, and infiltrative margins.
  • Follow-up in 15 patients showed 20% local recurrence and 20% distant metastasis, with some deaths from the disease.

Conclusions:

  • Pleomorphic Dermal Sarcoma may exhibit more aggressive behavior than previously estimated.
  • Incomplete surgical resection was associated with local recurrence.
  • The study highlights the need for careful monitoring and potentially more aggressive treatment strategies for PDS.