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Updated: Apr 5, 2026
Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
Published on: November 23, 2014
Tumour Angiogenesis and Angiogenic Inhibitors: A Review
Lalita Yadav1, Naveen Puri2, Varun Rastogi3
1Senior Lecturer, Department of Oral & Maxillofacial Pathology, Kalka Dental College , Meerut Uttar Pradesh, India .
Abstract:
Angiogenesis is a complex process depending on the coordination of many regulators and there by activating angiogenic switch. Recent advances in understanding of angiogenic mechanism have lead to the development of several anti-angiogenic and anti-metastatic agents that use the strategy of regulation of angiogenic switch. Antiangiogenic therapy is a form of treatment not cure for cancer and represents a highly effective strategy for destroying tumour because vascular supply is the fundamental requirement for growth of tumour. Because of the quiescent nature of normal adult vasculature, angiogenic inhibitors are expected to confer a degree of specificity when compared to nonspecific modalities of chemo and radiotherapy, so it has the advantage of less toxicities, does not induce drug resistance and deliver a relatively non toxic, long term treatment of tumour.
Insights
Antiangiogenic therapy targets tumor vascular supply by regulating the angiogenic switch, offering a less toxic, non-curative cancer treatment. This approach leverages the quiescent nature of normal vasculature for specificity and long-term tumor management.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Angiogenesis is crucial for tumor growth, involving complex regulators that activate the angiogenic switch.
- Understanding angiogenic mechanisms has led to targeted anti-angiogenic and anti-metastatic therapies.
- Tumor vascularization is essential for sustained tumor progression.
Purpose of the Study:
- To explore the role of the angiogenic switch in cancer progression.
- To highlight the therapeutic potential of anti-angiogenic agents.
- To discuss the advantages of targeting tumor vasculature.
Main Methods:
- Review of current literature on angiogenesis and anti-angiogenic therapies.
- Analysis of the mechanisms underlying the angiogenic switch.
- Comparison of anti-angiogenic therapy with traditional cancer treatments.
Main Results:
- Anti-angiogenic therapy is an effective strategy for tumor destruction by inhibiting vascular supply.
- Targeting the angiogenic switch offers a method to control tumor growth.
- Angiogenic inhibitors are expected to be more specific than traditional therapies.
Conclusions:
- Anti-angiogenic therapy represents a promising, less toxic treatment modality for cancer.
- The specificity of angiogenic inhibitors offers advantages in reducing side effects and drug resistance.
- This therapeutic strategy provides a non-toxic, long-term approach to tumor management.
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