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Updated: Apr 5, 2026

Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells
Published on: January 5, 2024
Ion-Induced Dipole Interactions and Fragmentation Times: Cα-Cβ Chromophore Bond Dissociation Channel
Satchin Soorkia1, Christophe Dehon1, Sunil Kumar S1
1†Institut des Sciences Moléculaires d'Orsay, CNRS UMR 8214, Université Paris Sud, F-91405 Orsay Cedex, France.
Abstract:
The fragmentation times corresponding to the loss of the chromophore (Cα-Cβ bond dissociation channel) after photoexcitation at 263 nm have been investigated for several small peptides containing tryptophan or tyrosine. For tryptophan-containing peptides, the aromatic chromophore is lost as an ionic fragment (m/z 130), and the fragmentation time increases with the mass of the neutral fragment. In contrast, for tyrosine-containing peptides the aromatic chromophore is always lost as a neutral fragment (mass = 107 amu) and the fragmentation time is found to be fast (<20 ns). These different behaviors are explained by the role of the postfragmentation interaction in the complex formed after the Cα-Cβ bond cleavage.
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