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[Intravascular coagulation in amniotic fluid embolism].

A Angelov

    Akusherstvo I Ginekologiia
    |January 1, 1989
    PubMed
    Summary

    Amniotic embolism (AE) in pregnant women often leads to intravascular coagulation (IC) and lung damage. Early detection of coagulation status and fibrinolytic activity is crucial for managing this critical condition.

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    Area of Science:

    • Obstetrics and Gynecology
    • Pathology
    • Hematology

    Context:

    • Amniotic embolism (AE) is a rare but often fatal complication during pregnancy and childbirth.
    • Understanding the pathological mechanisms of AE is critical for improving patient outcomes.
    • Previous studies have highlighted the association between AE and coagulation disorders.

    Purpose:

    • To investigate the clinicopathological features of amniotic embolism.
    • To determine the role of intravascular coagulation (IC) and fibrinolytic activity in AE pathogenesis.
    • To identify the primary factors contributing to mortality in AE cases.

    Summary:

    • Amniotic embolism (AE) was diagnosed in 8.13% of 160 deceased pregnant and parturient women.
    • Morphological and clinico-anatomical analyses revealed significant lung microcirculatory obstruction.
    • Intravascular coagulation (IC) was present in 84.6% of AE cases, with lungs being the most severely affected site.
    • AE exhibits a jerky course with a variable subclinical period and early fibrinolytic system activation.
    • Hyaline globules were observed within the first hour of AE onset, indicating early fibrinolysis.
    • IC, acute respiratory insufficiency, and consumption coagulopathy were identified as the main causes of death in AE.

    Impact:

    • This study underscores the importance of dynamic monitoring of coagulation status and fibrinolytic activity in AE patients.
    • Timely anticoagulant and antifibrinolytic therapy may improve survival rates.
    • Findings contribute to a better understanding of AE pathophysiology and management strategies.

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