Related Experiment Video
Updated: Apr 5, 2026
07:23
Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
Published on: May 30, 2025
1.3K
LincRNA-p21: Implications in Human Diseases
Sai-Sai Tang1,2,3, Bi-Ying Zheng4, Xing-Dong Xiong5,6,7,8
1Institute of Aging Research, Guangdong Medical University, Dongguan 523808, China. saisaitang1988@126.com.
International Journal of Molecular Sciences
|August 14, 2015
Summary
Long noncoding RNAs (lncRNAs) regulate biological processes. This review focuses on lincRNA-p21, highlighting its roles in cell functions and human diseases as a potential diagnostic and therapeutic target.
Area of Science:
- Molecular Biology
- Genetics
- Human Diseases
Background:
- Long noncoding RNAs (lncRNAs) are key regulators of biological processes, despite lacking protein-coding capacity.
- Their diverse molecular mechanisms are still being elucidated.
- Emerging research highlights lncRNAs' significant roles in human diseases.
Purpose of the Study:
- To review current knowledge on lincRNA-p21.
- To summarize its biological functions and molecular mechanisms.
- To highlight its involvement in human diseases for potential therapeutic applications.
Main Methods:
- Literature review of studies on lincRNA-p21.
- Analysis of documented biological functions.
- Examination of disease associations and mechanistic insights.
Main Results:
- lincRNA-p21 is implicated in cell proliferation, apoptosis, and DNA damage response.
- It plays a role in the initiation and progression of various human diseases.
- Evidence suggests its potential as a biomarker and therapeutic target.
Conclusions:
- lincRNA-p21 is a significant lncRNA with critical roles in cellular functions and disease pathogenesis.
- Further research into lincRNA-p21 mechanisms and disease associations is warranted.
- lincRNA-p21 represents a promising target for disease diagnostics and therapeutics.
Related Concept Videos
02:39lncRNA - Long Non-coding RNAs
10.2K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.2K
02:39lncRNA - Long Non-coding RNAs
3.9K
3.9K
01:12Loss of Tumor Suppressor Gene Functions
6.3K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
6.3K
01:12Loss of Tumor Suppressor Gene Functions
2.1K
2.1K
02:23Abnormal Proliferation
5.4K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.4K
02:55The Nucleolus
10.7K
The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
10.7K