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Splicing Regulators and Their Roles in Cancer Biology and Therapy

Maria Roméria da Silva1, Gabriela Alves Moreira1, Ronni Anderson Gonçalves da Silva1

  • 1Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, 36570-900 Viçosa, MG, Brazil.

Biomed Research International
|August 15, 2015
PubMed

Insights

Alternative splicing generates diverse proteins from single genes. In cancer, altered splicing factors create abnormal proteins, driving tumor growth, and highlighting splicing as a therapeutic target.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Biology

Background:

  • Alternative splicing expands the proteome from a limited genome.
  • Splicing patterns are context-dependent, yielding proteins with varied functions.
  • Aberrant splicing in cancer contributes to tumor progression.

Purpose of the Study:

  • To review dysregulated alternative splicing in cancer.
  • To examine key regulatory factors like SR proteins and their kinases (SRPKs, CLKs).
  • To discuss the potential of targeting the splicing machinery for cancer therapy.

Main Methods:

  • Literature review of alternative splicing in cancer.
  • Focus on SR proteins, SRPKs, and CLKs.
  • Analysis of splicing's role in cancer pathways.

Main Results:

  • Dysregulated alternative splicing is prevalent in cancer.
  • SR proteins and associated kinases are frequently altered in tumors.
  • Altered splicing promotes cancer cell growth and survival.

Conclusions:

  • Splicing machinery is a critical player in tumor biology.
  • Targeting splicing represents a promising avenue for novel anticancer therapies.

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