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Posttranscriptional Regulation of Splicing Factor SRSF1 and Its Role in Cancer Cell Biology

Vânia Gonçalves1, Peter Jordan1

  • 1Department of Human Genetics, National Health Institute Dr. Ricardo Jorge, Avenida Padre Cruz, 1649-016 Lisboa, Portugal ; Biosystems and Integrative Sciences Institute (BioISI), Faculty of Sciences, University of Lisbon, 1749-016 Lisboa, Portugal.

Biomed Research International
|August 15, 2015
PubMed

Insights

Alternative splicing, a key gene expression regulator, generates diverse messenger RNAs. This review focuses on SRSF1, a splicing factor, detailing its regulation and role in cancer progression.

Area of Science:

  • Molecular Biology
  • Gene Expression Regulation
  • Cancer Biology

Background:

  • Alternative splicing generates mRNA diversity, crucial for tissue-specific gene expression and disease states.
  • RNA-binding proteins orchestrate alternative splicing, with SRSF1 serving as a key regulatory factor.
  • Understanding splicing regulation is vital for comprehending cellular function and disease mechanisms.

Purpose of the Study:

  • To review the molecular mechanisms governing the SRSF1 splicing regulator.
  • To elucidate the posttranscriptional modifications impacting SRSF1's function and localization.
  • To summarize SRSF1's dysregulation in tumors and its impact on cancer cell biology.

Main Methods:

  • Literature review of molecular mechanisms and posttranscriptional modifications of SRSF1.
  • Analysis of SRSF1's alternative splicing, phosphorylation, and subcellular localization.
  • Compilation of data on SRSF1 expression in tumors and its regulated alternative transcripts.

Main Results:

  • SRSF1 undergoes complex regulation, including its own alternative splicing and posttranscriptional modifications like phosphorylation.
  • Nuclear and cytoplasmic localization of SRSF1 influences its regulatory functions.
  • Dysregulated SRSF1 expression is observed in various tumors, affecting cancer cell biology.

Conclusions:

  • SRSF1 is a critical splicing regulator with multifaceted control mechanisms.
  • Altered SRSF1 activity and expression contribute to tumor development and progression.
  • Further research into SRSF1's role can reveal therapeutic strategies for cancer.

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