Related Experiment Video
Updated: Apr 5, 2026

Mapping Dysfunctional Protein-Protein Interactions in Disease
Published on: October 24, 2025
DSviaDRM: an R package for estimating disease similarity via dysfunctional regulation mechanism
Jing Yang1, Su-Juan Wu1, Yi-Xue Li2
1School of Biotechnology, East China University of Science and Technology, Shanghai 200237, People's Republic of China, System biology group, Shanghai Center for Bioinformation Technology, Shanghai 201203, People's Republic of China.
Unlabelled:
Elucidation of human disease similarities has provided new insights into etiology, disease classification and drug repositioning. Since dysfunctional regulation would be manifested as the decoupling of expression correlation, disease similarity (DS) in terms of dysfunctional regulation mechanism (DRM) could be estimated by using a differential coexpression based approach, which is described in a companion paper. Due to the lack of tools for estimating DS from the viewpoint of DRM in public domain, we implemented an R package 'DSviaDRM' to identify significant DS via DRM based on transcriptomic data. DSviaDRM contains five easy-to-use functions, DCEA, DCpathway, DS, comDCGL and comDCGLplot, for identifying disease relationships and showing common differential regulation information shared by similar diseases.
Availability And Implementation:
DSviaDRM is available as an R package, with a user's guide and source code, at http://cran.r-project.org/web/packages/DSviaDRM/index.html.
Contact:
yyli@scbit.org or yxli@scbit.org.
Supplementary Information:
Supplementary data are available at Bioinformatics online.
Related Concept Videos
Neural Regulation
Covalently Linked Protein Regulators
These groups modify specific amino acids in a protein....
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Gene Regulation in Microbial Communities: Quorum Sensing
Mechanistic Models: Compartment Models in Individual and Population Analysis
Regulated Protein Degradation
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...

