Related Experiment Video
Updated: Apr 5, 2026

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
Published on: July 25, 2020
Hypothesis generation using network structures on community health center cancer-screening performance
Timothy Jay Carney1, Geoffrey P Morgan2, Josette Jones3
1Indiana University School of Informatics (IUPUI), United States; University of North Carolina, Gillings School of Global Public Health, United States; Global Health Equity Intelligence Collaborative (GHEIC), LLC, United States.
Community health centers can improve cancer screening rates by fostering collaboration and knowledge sharing. Computational modeling identified network characteristics linked to high performance, offering a strategic approach for sustained improvement.
Area of Science:
- Health Services Research
- Health Informatics
- Systems Science
- Network Theory
Background:
- Quality improvement initiatives in community health centers aim to boost cancer screening rates.
- Despite efforts, screening rates often fall short of benchmarks and are difficult to sustain.
- Organizational complexity and dynamic environments challenge consistent performance improvements.
Purpose of the Study:
- To understand factors influencing cancer screening performance in community health centers over time.
- To apply computational modeling to analyze organizational dynamics and screening outcomes.
- To identify network characteristics associated with high-performing centers.
Main Methods:
- Utilized Construct-TM, a multi-agent network evolution model, to simulate community health centers.
- Incorporated point-in-time survey data to differentiate simulated high and low performers.
- Analyzed knowledge acquisition, retention, sharing, and clinical decision support impacts on screening rates.
Main Results:
- High-performing centers exhibited greater network symmetry, agent cohesion, and connectedness.
- These centers showed higher collaboration, faster knowledge absorption, and better access to knowledge resources.
- Computational models successfully distinguished between high and low performers based on network characteristics.
Conclusions:
- Distinct network patterns characterize high-performing community health centers regarding interaction and knowledge resource utilization.
- Non-network data can forecast organizational performance, aiding sustainable, long-term strategic improvement.
- Computational modeling offers insights into organizational performance in complex healthcare settings.
More Related Videos
07:13Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model
Published on: April 18, 2025
10:24Generation of Heterogeneous Drug Gradients Across Cancer Populations on a Microfluidic Evolution Accelerator for Real-Time Observation
Published on: September 19, 2019
Related Concept Videos
Models of Health Promotion and Illness Prevention I
The health belief model (HBM) attempts to predict health-related behavior in specific belief patterns. According to the HBM, a person's...
Cancer Survival Analysis
Models of Health Promotion and Illness Prevention II
The agent-host-environment model states that disease results...
Comparing the Survival Analysis of Two or More Groups
Investigation of Disease Outbreaks
Study Designs in Epidemiology
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...