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Probiotic Studies in Neonatal Mice Using Gavage
Published on: January 27, 2019
[PROBIOTICS, NUTRITIONAL STATUS AND RESISTANCE TO RESPIRATORY INFECTIONS IN INFANTS]
Insights
Probiotic use of Enterococcus faecium L3 in infants reduced acute respiratory infections (ARI) and improved body mass index (BMI) in the first month. This probiotic intervention also supported vaccination schedules in infants.
Area of Science:
- Pediatrics
- Microbiology
- Immunology
Context:
- Infants in institutional care are susceptible to infections.
- Acute Respiratory Infections (ARI) are a common health concern in infants.
- Nutritional status is crucial for infant development and immunity.
Purpose:
- To evaluate the efficacy of a liquid probiotic Enterococcus faecium L3 in preventing ARI in infants.
- To assess the impact of this probiotic on infant nutritional status.
- To determine the probiotic's effect on infant vaccination tolerance.
Summary:
- A randomized controlled trial involved 29 infants, with 14 receiving daily Enterococcus faecium L3 probiotic and 15 in the control group.
- The probiotic group showed a significant reduction in ARI cases (p < 0.05) and a higher increase in Body Mass Index (BMI) during the first month.
- Probiotic use was associated with improved tolerance for routine vaccinations, with 18.1% more infants receiving multiple vaccinations simultaneously.
Impact:
- Probiotic supplementation with Enterococcus faecium L3 may enhance infant immunity against respiratory infections.
- Early probiotic intervention can positively influence infant growth and nutritional parameters.
- This probiotic may facilitate the timely completion of infant vaccination schedules.
Abstract:
Aim of this study was to investigate the efficacy of prophylactic use of a liquid probiotic form based on Enterococcus faecium L3 in children first year of life to increase resistance to acute respiratory infections (ARI) in the winter-spring period and improve nutritional status. In a specialized (psychoneurologic) orphanage of St. Petersburg within three months of winter-spring period in 2014 observed 29 children in the first year of life. Observed children were randomly divided into two groups. The main group (n = 14) within three months received daily per os liquid probiotic form based on E.faecium L3 in a daily dose of 1.5 x 10(9) CFU. A control group of children (n = 15) was comparable with the main group by gender and age. The children observed groups studied the incidence of ARI; number of vaccinated children; the number of children who received two or more vaccinations at the same time; the number of children with acute infectious diseases within 1 month after vaccination; dynamics of Chulitskaya index, body mass index, body weight and length. The data obtained are subjected to statistical analysis, the results were considered significant at p < 0.05. The results showed that the use of probiotic forms E.faecium L3 in infants helped to reduce the average number of ARI cases per child (0.29 ± 0.13 vs. 0.73 ± 0.12 in the control group; p < 0.05) only in the first month of the observation that combined with a significantly higher BMI values increase this month (0.54 ± 0.25 vs. 0.07 ± 0.22 kg/m2 in the control group; p < 0.05). Use the liquid probiotic form E.faecium L3 in infants had a positive impact on overall health, which is reflected in the implementation of routine vaccination activities--in the main group, the number of children who received two or more vaccinations at the same time was 18.1% more.
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