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[PEDIATRIC GASTROENTEROLOGY: ORIGINS, PROBLEMS, AND PROSPECTS OF THE RESEARCH].

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[The evolution of understanding the concept of biliary tract diseases in childhood].

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[Risk factors and mechanisms of the postcholecystectomy syndrome development in children].

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[ENZYME THERAPY OF POSTCHOLECYSTECTOMY SYNDROME IN CHILDREN].

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    Eksperimental'Naia I Klinicheskaia Gastroenterologiia = Experimental & Clinical Gastroenterology
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    Enzyme replacement therapy (ERT) is effective for managing postcholecystectomy syndrome (PHES) in children. This approach, particularly using Creon, helps correct pancreatic function with manageable side effects across various age groups.

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    Area of Science:

    • Pediatric Gastroenterology
    • Pharmacology
    • Digestive Health

    Context:

    • Postcholecystectomy syndrome (PHES) can significantly impact children's digestive health after gallbladder removal.
    • Exocrine pancreatic insufficiency is a common complication requiring therapeutic intervention.
    • Optimizing treatment strategies for pediatric PHES is crucial for improving patient outcomes.

    Purpose:

    • To provide pathogenetic justification for the efficacy of enzyme replacement therapy (ERT) in pediatric postcholecystectomy syndrome (PHES).
    • To evaluate the applicability and effectiveness of ERT in children across different age demographics with PHES.
    • To detail the mechanism of action, potential side effects, and benefits of specific ERT agents, like Creon, in managing PHES.

    Summary:

    • The article advocates for enzyme replacement therapy (ERT) as a key treatment for postcholecystectomy syndrome (PHES) in pediatric patients.
    • It highlights the successful application of ERT, specifically Creon, in addressing exocrine pancreatic dysfunction in children with PHES.
    • The study discusses the safety profile and therapeutic advantages of ERT, emphasizing its role in different pediatric age groups.

    Impact:

    • Establishes a strong rationale for incorporating ERT into the standard care for pediatric PHES.
    • Provides evidence supporting the use of Creon for improving pancreatic function and alleviating symptoms in affected children.
    • Offers insights into age-specific considerations for ERT administration in pediatric gastroenterology practice.