Related Experiment Video

Updated: Apr 5, 2026

In Vitro and In Vivo Approaches to Determine Intestinal Epithelial Cell Permeability
10:22

In Vitro and In Vivo Approaches to Determine Intestinal Epithelial Cell Permeability

Published on: October 19, 2018

27.1K

[Study on effect of pH on rectum permeability of active ingredients in Reduning suppositories in vitro]

Ming Yan, Ying-chun Wei, Jin Meng

    Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
    |August 19, 2015
    PubMed
    Abstract

    More Related Videos

    An In Vivo Method for Evaluating the Gut-Blood Barrier and Liver Metabolism of Microbiota Products14:54

    An In Vivo Method for Evaluating the Gut-Blood Barrier and Liver Metabolism of Microbiota Products

    Published on: October 20, 2018

    9.0K
    Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis08:58

    Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

    Published on: January 5, 2017

    13.0K

    Related Concept Videos

    Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

    Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

    Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
    668
    Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH01:21

    Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH

    Drug absorption within the gastrointestinal (GI) tract is a complex process influenced by several critical factors, including the site pH, the drug's dissociation constant (pKa), and the drug's lipophilicity. The GI tract exhibits a pH gradient, with an acidic environment in the stomach and a more alkaline environment in the small intestine. This pH variation directly affects the ionization state of drugs.
    A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles...
    4.3K
    Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

    Factors Influencing Drug Absorption: Pharmaceutical Parameters

    Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
    768
    Factors Influencing Drug Absorption: Drug Dissolution01:27

    Factors Influencing Drug Absorption: Drug Dissolution

    The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
    1.6K
    Methods for Studying Drug Absorption: In vitro01:16

    Methods for Studying Drug Absorption: In vitro

    In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
    The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
    767
    Methods for Studying Drug Absorption: In situ01:09

    Methods for Studying Drug Absorption: In situ

    In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
    The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
    842