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A dual-FRET-based fluorescence probe for the sequential detection of MMP-2 and caspase-3
Shi-Ying Li1, Li-Han Liu, Hong Cheng
1Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China. xz-zhang@whu.edu.cn.
Chemical Communications (Cambridge, England)
|August 19, 2015
Abstract:
A novel dual-FRET-based fluorescence probe was designed and synthesized for the sequential detection of MMP-2 and caspase-3. This probe can successfully monitor Dox- and UV-induced cell apoptosis signals in real time and in situ, which demonstrated its great potential for apoptosis-related drug screening and dynamic apoptosis imaging.
