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Rapid 3D Extrusion of Synthetic Tumor Microenvironments
Joshua M Grolman1, Douglas Zhang1, Andrew M Smith2
1Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Advanced Materials (Deerfield Beach, Fla.)
|August 19, 2015
Abstract:
The spatial positioning of 3D tumor-mimetic microenvironments, containing multiple cell types, is controlled with a simple concentric flow device in a single step. A range of geometric architectures are demonstrated, and the migration of segregated tumor cells and macrophages is explored using drugs that inhibit heterotypic interactions.
