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Lipid profile but not highly sensitive C-reactive protein helps distinguish prehypertensives from normal subjects
1Department of Physiology, JSS Medical College, SS Nagar, Mysore, Karnataka, India.
Insights
Prehypertension is linked to higher total cholesterol and LDL levels, but not hsCRP. Early identification of prehypertension aids disease risk management.
Area of Science:
- Cardiovascular Health
- Biomarkers
- Hypertension Research
Background:
- Early identification of prehypertension is crucial for managing cardiovascular disease risk.
- While hypertension is associated with elevated hsCRP and dyslipidemia, their role in prehypertension is unclear.
- This study investigates serum hsCRP and lipid profiles in prehypertensive individuals.
Purpose of the Study:
- To compare serum hsCRP and lipid profiles between prehypertensive and normal subjects.
- To correlate these biomarkers with blood pressure levels in prehypertensives.
- To identify potential early indicators of cardiovascular risk in the prehypertensive state.
Main Methods:
- 40 prehypertensive and 40 normal subjects were enrolled.
- Blood pressure and anthropometric measurements were recorded.
- Serum hsCRP and lipid profiles (including Total Cholesterol and LDL) were analyzed and correlated with BP.
Main Results:
- Serum hsCRP levels did not differ significantly between prehypertensive and normal groups.
- No significant correlation was found between blood pressure and hsCRP in either group.
- Prehypertensive subjects showed significantly higher Total Cholesterol and LDL levels compared to normal subjects.
Conclusions:
- Prehypertension is associated with increased Total Cholesterol and LDL, indicating dyslipidemia.
- Serum hsCRP levels do not appear to be an early marker for prehypertension.
- These findings highlight the importance of monitoring lipid profiles in individuals with prehypertension.
Background:
Early identification of the prehypertensive state can greatly improve the disease risk management. Although increased levels of highly sensitive C-reactive protein (hsCRP) and dyslipidemia is reported among patients with hypertension, the correlation of these parameters among prehypertensives in not known. Hence, the present study was designed to compare the levels of serum hsCRP and lipid profile among prehypertensives and normal subjects and correlate it with blood pressure (BP) levels.
Materials And Methods:
Anthropometric measurements and BP were recorded in 40 prehypertensive and 40 normal subjects. Subjects were assigned to a group based on their BP as per Joint National Committee 7 criteria. Serum hsCRP and lipid profile were measured and correlated with BP levels.
Results:
Serum hsCRP showed no significant difference between the two groups. There was no significant correlation of BP with hsCRP in both the groups. Total cholesterol (TC) and low-density lipoprotein (LDL) were significantly increased in prehypertensives as compared to normal subjects. There was no significant association between BP and lipid parameters in prehypertensives.
Conclusions:
Significant increase of TC and LDL but not hsCRP was evident among prehypertensives as compared to normal subjects.
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