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Updated: Apr 5, 2026

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
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Published on: July 17, 2020

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Focus on PTEN Regulation

Miriam Bermúdez Brito1, Evangelia Goulielmaki1, Evangelia A Papakonstanti1

  • 1Department of Biochemistry, School of Medicine, University of Crete , Heraklion , Greece.

Frontiers in Oncology
|August 19, 2015
PubMed
Summary

Phosphatase and tensin homolog (PTEN) is a tumor suppressor. Its functions extend beyond lipid phosphatase activity, involving diverse cellular locations and complex regulatory mechanisms impacting human diseases.

Keywords:
PTENlocalizationprotein interactionstranscriptiontranslation

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