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Evaluation of Macular Function Using Pattern Electroretinogram in Idiopathic Epiretinal Membrane
Min Kyu Shin1, Sung Il Kim, Sung Who Park
1From the *Department of Ophthalmology, School of Medicine, Pusan National University, Yangsan; †Medical Institute, Pusan National University Hospital, Busan; ‡Research Institute for Convergence of Biomedical Science and Technology, Yangsan Pusan National University Hospital, Yangsan; and §Department of Ophthalmology, Busan Paik Hospital, College of Medicine, Inje University, Busan, South Korea.
Pattern electroretinogram (PERG) revealed that the N95 amplitude predicts visual outcomes after epiretinal membrane (ERM) surgery. This highlights the ganglion cell layer
Area of Science:
- Ophthalmology
- Retinal Diseases
- Visual Electrophysiology
Background:
- Idiopathic epiretinal membrane (ERM) can affect visual acuity by distorting the retinal layers.
- Assessing ganglion cell function preoperatively may predict surgical outcomes.
Purpose of the Study:
- To investigate the correlation between pattern electroretinogram (PERG) parameters and postoperative visual acuity in idiopathic ERM.
- To determine if ganglion cell function, assessed by PERG, predicts visual recovery after ERM surgery.
Main Methods:
- Retrospective chart review of 24 eyes undergoing vitrectomy and membrane peeling for idiopathic ERM.
- Analysis of preoperative PERG P50 and N95 wave amplitudes and implicit times.
- Correlation of PERG parameters with visual acuity and foveal thickness, using ratios compared to healthy fellow eyes.
Main Results:
- Visual acuity improved significantly six months post-surgery (P=0.003), and foveal thickness decreased (P=0.001).
- The preoperative N95 amplitude ratio showed a significant correlation with visual acuity at six months (r=-0.423, P=0.040).
- Implicit times of P50 and N95 waves correlated significantly with preoperative foveal thickness (P=0.008 and P=0.033, respectively).
Conclusions:
- The N95 amplitude in PERG is a significant predictor of visual outcomes following ERM surgery.
- Postoperative visual acuity is correlated with the function of the ganglion cell layer, the layer most affected by ERM.
