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Airway resistance and allergic sensitization in children with obstructive sleep apnea hypopnea syndrome

Jie Zhang1, Jing Zhao1, Min Chen1

  • 1Department of Otorhinolaryngology, Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Beijing Children's Hospital, Head and Neck Surgery Beijing Pediatric Research Institute, Capital Medical University, Beijing, P. R. China.

Pediatric Pulmonology
|August 19, 2015
PubMed

Insights

Total airway resistance is elevated in children with obstructive sleep apnea hypopnea syndrome (OSAHS). Allergic sensitization may worsen OSAHS severity in pediatric patients, warranting further research.

Area of Science:

  • Pediatric Pulmonology
  • Sleep Medicine
  • Allergy and Immunology

Background:

  • Obstructive sleep apnea hypopnea syndrome (OSAHS) is a common condition in children.
  • Airway resistance and allergic sensitization are potential factors influencing OSAHS severity.

Purpose of the Study:

  • To measure airway resistance in Chinese children with OSAHS using impulse oscillometry (IOS).
  • To investigate the relationship between OSAHS severity, airway resistance, and allergic sensitization.

Main Methods:

  • 120 children were assessed, with 93 diagnosed with OSAHS.
  • Airway resistance (R5, R20, X5) was measured by IOS.
  • Serum total IgE and allergen-specific IgE (sIgE) levels were determined.

Main Results:

  • Total airway resistance (R5) was significantly higher in children with OSAHS compared to controls.
  • R5 correlated positively with OSAHS severity indices (AHI, OAI) and negatively with oxygen saturation.
  • Increased R5 and total IgE were more prevalent in severe OSAHS cases.

Conclusions:

  • Children with OSAHS exhibit significantly increased total airway resistance.
  • Allergic sensitization may contribute to the exacerbation of pediatric OSAHS.
  • Further large-scale studies are needed to confirm these findings.
Abstract

Keywords:
airway resistanceallergenchildrenimpulse oscillometryobstructive sleep apnea hypopnea syndrome

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