Related Experiment Video
Updated: Apr 5, 2026
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
12.5K
[Relationship between vitamin D receptor gene polymorphisms and chronic periodontitis]
Xiao-jing Cao1, Lu He1, Huan-xin Meng1
1Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing 100081, China.
Summary
Vitamin D receptor (VDR) gene polymorphisms, specifically rs1544410 and rs731236, are linked to severe chronic periodontitis (CP) in the Chinese Han population. These VDR gene variations may increase the risk for developing severe forms of this common gum disease.
Area of Science:
- Genetics
- Periodontology
- Molecular Biology
Context:
- Chronic periodontitis (CP) is a prevalent inflammatory disease affecting the gums and supporting structures of teeth.
- The vitamin D receptor (VDR) plays a crucial role in immune regulation and bone metabolism, both relevant to periodontal health.
- Genetic variations in the VDR gene may influence an individual's susceptibility to CP.
Purpose:
- To investigate the association between specific VDR gene polymorphisms (rs1544410 and rs731236) and the severity of chronic periodontitis.
- To analyze genotype and allele frequencies of these VDR polymorphisms in patients with mild/moderate versus severe CP.
- To determine if VDR gene variations contribute to the risk of developing severe chronic periodontitis in the Chinese Han population.
Summary:
- This study genotyped VDR polymorphisms rs1544410 and rs731236 in 190 Chinese Han individuals (105 mild/moderate CP, 85 severe CP).
- Significantly higher frequencies of the rs1544410 A allele and AA+AG genotype were observed in severe CP cases compared to mild/moderate cases, particularly in females.
- Similarly, the rs731236 C allele and CC+CT genotype were more prevalent in severe CP patients, especially females, indicating a strong association.
Impact:
- The findings suggest that VDR gene polymorphisms rs731236 and rs1544410 are potential genetic markers for severe chronic periodontitis.
- Understanding these genetic associations can aid in identifying individuals at higher risk for severe CP.
- This research contributes to the genetic basis of periodontal disease and may inform future personalized prevention or treatment strategies.
Related Concept Videos
01:29Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
114
Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
114
01:11Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
69
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
69
01:27Pharmacogenetics of Drug Metabolism: Overview
125
Genetic polymorphism in drug metabolism is crucial to the inter-individual variability observed in drug responses. Drug metabolism primarily involves the chemical modification of drugs and other xenobiotics to enhance their elimination by increasing their polarity. Two main classes of enzymes mediate this biotransformation process: Phase I enzymes, primarily cytochrome P450s, catalyze oxidation and reduction reactions, while other enzymes, such as esterases, mediate hydrolysis, and Phase II...
125
01:05Single Nucleotide Polymorphisms-SNPs
19.9K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
19.9K
01:27Principles of Pharmacogenetics: Types of Genetic Variants
98
The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
98
01:27The Oral Microbiota
41
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
41