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Fatigue

Fatigue

Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Related Experiment Video

Updated: Apr 5, 2026

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

Cancer-Related Fatigue, Version 2.2015.

Ann M Berger, Kathi Mooney, Amy Alvarez-Perez

Journal of the National Comprehensive Cancer Network : JNCCN

|August 19, 2015

Summary

This summary is machine-generated.

Cancer-related fatigue is a common, distressing side effect impacting patients

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Last Updated: Apr 5, 2026

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

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Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

Area of Science:

Oncology
Patient Care

Background:

Cancer-related fatigue (CRF) is a prevalent and distressing subjective experience impacting physical, emotional, and cognitive well-being in cancer patients.
CRF is not proportional to activity and significantly interferes with daily functioning, persisting during and after cancer treatment.
This persistent fatigue complicates end-of-life care and is often underreported, leading to reduced quality of life.

Purpose of the Study:

To outline the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Cancer-Related Fatigue.
To provide evidence-based guidance on screening for CRF and recommend interventions.
To emphasize the importance of routine screening for CRF to improve patient quality of life.

Main Methods:

Review and synthesis of existing literature and clinical guidelines.
Development of recommendations for screening and management strategies.
Categorization of interventions based on treatment stage, including education, counseling, and specific nonpharmacologic and pharmacologic approaches.

Main Results:

CRF is a common, persistent side effect of cancer and its treatment.
A range of interventions, including education, counseling, and pharmacologic/non-pharmacologic methods, can manage CRF.
Routine screening is crucial for identifying and addressing CRF.

Conclusions:

Implementing NCCN Guidelines for CRF screening and management is essential.
Proactive identification and intervention for CRF can significantly improve patients' quality of life.
Addressing CRF is a critical component of comprehensive cancer care.