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Visualization of Scattered Tumor Regression Following Neoadjuvant Chemoimmunotherapy With a Novel Intraoperative
Andreja Radevic1, Joaquin Austerlitz1, Ashtyn McAdoo1,2,3
1Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Head & Neck
|May 25, 2026
Summary
Neoadjuvant chemoimmunotherapy can cause multifocal regression in head and neck squamous cell carcinoma (HNSCC). Intraoperative imaging helps map residual tumor and treatment effects, guiding further research.
Area of Science:
- Oncology
- Surgical Oncology
- Immunotherapy
Background:
- Neoadjuvant chemoimmunotherapy is under investigation for locally advanced head and neck squamous cell carcinoma (HNSCC).
- The spatial distribution of pathological responses and their clinical significance in HNSCC are not well understood.
- A patient with recurrent oral tongue SCC received neoadjuvant therapy prior to surgery.
