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Updated: Apr 5, 2026

A Reversible Silicon Oil-Induced Ocular Hypertension Model in Mice
Published on: November 15, 2019
Persistent anterior chamber silicone oil and myopia
Stephen J Vincent1, Roslyn A Vincent1, Les M Manning1
1From the School of Optometry and Vision Science (S.J. Vincent), Queensland University of Technology, the City Eye Centre (R.A. Vincent, Lee), the Watkins Medical Centre (Manning), and the University of Queensland (Lee), Brisbane, Queensland, Australia.
Attempted removal of heavy silicone oil after retinal detachment surgery caused a severe 20-diopter myopic shift. This case highlights potential ocular complications from silicone oil migration, necessitating surgical intervention.
Area of Science:
- Ophthalmology
- Retinal Surgery
- Vitreoretinal Diseases
Background:
- Silicone oil is used to treat retinal detachment with proliferative vitreoretinopathy.
- Heavy silicone oil was utilized in this patient's treatment.
- No financial or proprietary interests were disclosed by the authors.
Observation:
- A 60-year-old male presented with a significant unilateral myopic shift of 20 diopters.
- This occurred after an attempted removal of intravitreal heavy silicone oil.
- Examination showed heavy silicone oil on the corneal endothelium, obscuring the pupil.
Findings:
- Silicone oil migration into the anterior chamber was observed.
- Corneal endothelial decompensation occurred.
- A substantial increase in myopia was documented.
Implications:
- Silicone oil in the anterior chamber can lead to serious ocular complications.
- Corneal endothelial decompensation is a risk.
- Surgical intervention may be required to restore vision and manage complications.
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