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Subsampling versus bootstrapping in resampling-based model selection for multivariable regression.

Riccardo De Bin1, Silke Janitza1, Willi Sauerbrei2

  • 1Department of Medical Informatics, Biometry and Epidemiology, University of Munich, Marchioninistr. 15, 81377 Munich, Germany.

Biometrics
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Summary
This summary is machine-generated.

Subsampling offers advantages over the bootstrap for assessing multivariable regression model stability. This method, using inclusion frequencies, provides reliable variable selection and model assessment in regression analysis.

Keywords:
BootstrapModel selectionModel stabilitySubsampling

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Area of Science:

  • Statistics
  • Econometrics
  • Machine Learning

Background:

  • Multivariable regression models require stability assessment to ensure resistance to minor data fluctuations.
  • Resampling techniques, particularly the bootstrap, are commonly used to evaluate model stability and variable importance.
  • Potential limitations of the bootstrap have prompted interest in alternative methods like subsampling.

Purpose of the Study:

  • To empirically compare the bootstrap and subsampling techniques for assessing multivariable regression model stability.
  • To investigate the impact of these resampling methods on classical variable selection procedures.
  • To evaluate model selection and variable inclusion frequencies derived from both techniques.

Main Methods:

  • Implementation of variable selection procedures (e.g., backward elimination) on bootstrap and subsample datasets.
  • Calculation of model selection frequencies and variable inclusion frequencies for each resampling method.
  • Empirical comparison through analysis of two real-world datasets and a comprehensive simulation study.

Main Results:

  • Subsampling demonstrated advantages over the bootstrap in the context of multivariable regression model stability assessment.
  • Variable inclusion frequencies derived from subsampling provided robust insights into variable importance and model reliability.
  • The study identified specific scenarios where subsampling outperforms the bootstrap in maintaining model integrity.

Conclusions:

  • Subsampling is a viable and potentially superior alternative to the bootstrap for enhancing the stability analysis of regression models.
  • The findings support the adoption of subsampling for more reliable variable selection and model evaluation in statistical modeling.
  • Further research into subsampling's application across diverse regression techniques is warranted.