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Oral bisphosphonates and colon cancer: an update
Pia Eiken1, Peter Vestergaard2
1Department of Cardiology, Nephrology and Endocrinology, NOH Hillerød Hospital, Dyrehavevej 29, DK-3400 Hillerød, Denmark and Faculty of Health Sciences, University of Copenhagen, Denmark.
Abstract:
Bisphosphonates (BPs) are widely used as the main treatment for osteoporosis. In vitro and animal studies suggest that use of BPs may have a potential for colorectal cancer (CRC) prevention. Safety and efficacy in terms of osteoporosis prevention have only been evaluated in randomized controlled trials (RCTs) of relatively short duration (3-5 years), with smaller extension studies. The evidence for a benefit beyond 5 years is limited and intake of BPs has not shown any relationship with CRC in intervention studies. Observational studies and meta-analysis have shown unchanged or decreased risk of CRC. BPs used for treatment and prevention of osteoporosis should not be applied for prevention of CRC in clinical practice.
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