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Updated: Apr 5, 2026

A Mouse Model of Intestinal Partial Obstruction
Published on: March 5, 2018
Management of intestinal obstruction in advanced malignancy
Henry John Murray Ferguson1, Claire Irene Ferguson2, John Speakman2
1Department of Colorectal Surgery, Queen Elizabeth Hospital, Mindelsohn Way, Birmingham B15 2TH, UK.
Patients with advanced cancer may experience intestinal obstruction. Delaying surgery allows for spontaneous resolution and careful consideration of palliative care, as operations are high-risk.
Area of Science:
- Surgical Oncology
- Palliative Care
- Gastroenterology
Background:
- Advanced abdominal or pelvic malignancy frequently leads to intestinal obstruction in surgical patients.
- Bowel strangulation is rare in these cases, and spontaneous resolution is common, necessitating a cautious approach to surgical intervention.
Purpose of the Study:
- To outline the management of intestinal obstruction in patients with incurable advanced malignancy.
- To emphasize the importance of palliative care and informed decision-making regarding surgical intervention.
Main Methods:
- Review of clinical presentations and diagnostic imaging (cross-sectional imaging) for intestinal obstruction in advanced malignancy.
- Discussion of medical management including anti-emetics, anti-secretories, and analgesics.
- Consideration of surgical intervention versus palliative care.
Main Results:
- Most patients with advanced malignancy and obstruction are not surgical candidates.
- Palliative medicine consultation is crucial for optimal management.
- Resection with primary anastomosis may offer improved survival compared to bypass or stoma.
Conclusions:
- Management requires a multidisciplinary approach, involving patients, caregivers, and healthcare teams.
- Realistic prognostication is essential for informed treatment decisions.
- Surgery for this patient group is associated with high morbidity and limited data on quality of life.
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