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Acute pancreatitis following semaglutide therapy: a case report

Rabia Khalid Alduraibi¹, Nagwa Abdurrahman Fattouta¹, Yosef Fahad Altowayan¹

¹Department of Endocrine and Diabetes, King Fahad Specialist Hospital, Buraydah, Saudi Arabia.

Annals of Medicine and Surgery (2012)

|September 11, 2026

Abstract

Background:

Acute pancreatitis (AP) is a potentially life-threatening condition that can result from various aetiologies. While gallstones and alcohol consumption are the most common causes, medications can also induce AP. In the absence of a clear cause, drug-induced acute pancreatitis (DIAP) may pose challenges for clinicians. This is especially true when addressing unusual and rare causes such as glucagon-like peptide-1 receptor agonists.

Case Presentation:

A 41-year-old Saudi man was admitted to the hospital with epigastric pain after receiving subcutaneous semaglutide for weight loss. Laboratory test results revealed AP.

Conclusions:

In conclusion, semaglutide-induced acute pancreatitis is a rare but serious adverse effect. Clinicians should be aware of this potential adverse effect, particularly in patients without a history of diabetes mellitus who are using the drug for weight loss. Early recognition and discontinuation of the drug are crucial for the management of this condition.

Keywords:

GLP-1 RA acute pancreatitis drug-induced acute pancreatitis obesity semaglutide

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