Related Experiment Video

Updated: Apr 5, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.9K

High-Density Lipoprotein Subfractions and Their Oxidized Subfraction Particles in Patients with Chronic Kidney

Hirokazu Honda1, Tsutomu Hirano, Masashi Ueda

  • 1Division of Nephrology, Department of Medicine, Showa University Koto Toyosu Hospital.

Journal of Atherosclerosis and Thrombosis
|August 21, 2015
PubMed

Insights

In chronic kidney disease (CKD), altered high-density lipoprotein (HDL) subfractions and increased oxidized HDL particles are linked to cardiovascular disease (CVD) events. These changes, particularly oxidized HDL2, are independent risk factors for CVD in CKD patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Biochemistry

Background:

  • Chronic kidney disease (CKD) is associated with dyslipidemia, including altered high-density lipoprotein (HDL) levels.
  • Oxidative stress and inflammation in CKD can damage HDL particles, potentially increasing cardiovascular disease (CVD) risk.

Purpose of the Study:

  • To investigate the relationship between changes in HDL subfractions (HDL2, HDL3) and their oxidized forms with CVD events in CKD patients.
  • To determine if oxidized HDL particles are independent predictors of CVD in individuals with CKD.

Main Methods:

  • Measured total cholesterol, LDL-C, HDL-C, HDL2, HDL3, apolipoproteins, MDA-LDL, and oxidized HDL (oxHDL, oxHDL2, oxHDL3) in CKD patients (stages 2-5, n=86) and hemodialysis patients (stage 5D, n=25).
  • Followed patients for 28±9 months to record CVD events.
  • Utilized Cox proportional hazards models for multivariate analyses.

Main Results:

  • HDL3 and ApoA1 levels in HDL3 decreased with CKD severity; HDL2 and ApoA1 in HDL2 showed no significant difference.
  • Oxidized HDL2 levels increased with CKD severity, while oxHDL3 and MDA-LDL decreased.
  • High levels of oxidized HDL and its subfractions were identified as independent risk factors for CVD events in CKD patients.

Conclusions:

  • HDL subfractions and their oxidized forms exhibit distinct patterns in CKD patients.
  • Increased levels of oxidized HDL subfractions are implicated in the high incidence of CVD events observed in CKD populations.
Abstract

More Related Videos

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

15.2K
Assessment of Vascular Function in Patients With Chronic Kidney Disease08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.9K

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
970
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
1.2K
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
627
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
308
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
549
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
854