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Facile Preparation of 4-Substituted Quinazoline Derivatives
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Facile Preparation of 4-Substituted Quinazoline Derivatives

Published on: February 15, 2016

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A mild and regioselective route to functionalized quinazolines

Tracy M M Maiden1, Stephen Swanson2, Panayiotis A Procopiou2

  • 1Department of Chemistry, University of Sheffield, Sheffield, S3 7HF (UK).

Chemistry (Weinheim an Der Bergstrasse, Germany)
|August 21, 2015
PubMed
Summary

A new Rh-catalyzed reaction efficiently synthesizes 4-aminoquinazolines. This mild method rapidly accesses biologically active compounds using C(sp(2))-H activation.

Keywords:
amidationcyclizationhomogeneous catalysisoxazolinesquinazolines

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