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Umbilical Cord Coiling and Zygosity: Is there a Link?
André Joannou Coetzee1, Eumenia Castro2, Luiz Cesar Peres1
1a Department of Histopathology , Sheffield Children's Hospital , Western Bank , United Kingdom.
Fetal and Pediatric Pathology
|August 21, 2015
Summary
Umbilical coiling index (UCI) abnormalities in twin gestations were analyzed. Zygosity did not significantly influence umbilical coiling, indicating no genetic role in this process.
Area of Science:
- Perinatology
- Genetics
- Fetal Development
Background:
- The umbilical coiling index (UCI) assesses the degree of umbilical cord twisting.
- Abnormalities in umbilical coiling are associated with adverse pregnancy outcomes.
- Twin gestations present unique developmental considerations.
Purpose of the Study:
- To investigate umbilical coiling index (UCI) variations in twin pregnancies.
- To determine if zygosity influences the genetic control of umbilical coiling.
Main Methods:
- Retrospective analysis of twin gestation data.
- Inclusion of gestational age, chorionicity, fetal gender, and UCI.
- Comparison of UCI between monochorionic and dichorionic placentas.
Main Results:
- Mean UCI for hypercoiled cords in monochorionic placentas was 0.55 coils/cm.
- Mean UCI for hypercoiled cords in dichorionic placentas with discordant fetal gender was 0.49 coils/cm.
- No statistically significant difference in UCI was observed between the groups (P = 0.2629).
Conclusions:
- Zygosity does not appear to play a role in the induction of umbilical coiling.
- No significant statistical difference in UCI between monochorionic and dichorionic twin placentas with discordant fetal gender was identified.
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