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Updated: Apr 5, 2026
A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
19(4→3)-abeo-abietane diterpenoids from Scrophularia dentata Royle ex Benth
Liuqiang Zhang1, Dawei Zhang2, Qi Jia1
1School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, People's Republic of China.
Abstract:
Five 19(4→3)-abeo-abietane diterpenoids, scrodentoids A-E (1-5), were isolated from the whole plant of Scrophularia dentata. Planar structures of scrodentoids A-E were elucidated mainly by using 1D, 2D NMR and MS data. The absolute configurations of compounds 1 and 2 were established using X-ray crystallographic analysis. The absolute configurations of other compounds were confirmed using HPLC-UV/CD detection. The immunosuppressive effects of compounds 1-5 were studied using a ConA-induced splenocyte proliferation model. These compounds significantly inhibited ConA-induced splenocyte proliferation, with IC50 values in the range of 3.49-133.86 μM. Compounds 1-5 (IC50>10 μM) showed no discernible cytotoxic activity against B16 or MCF-7 cells.
