Related Experiment Video
Updated: Apr 5, 2026
12:04
The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
19.1K
Review article: BK virus in systemic lupus erythematosus
Nirupama Gupta1, Robert M Lawrence2, Cuong Nguyen3
1Division of Nephrology, Department of Pediatrics, College of Medicine, University of Florida, Gainesville, FL, 32610, USA. peacock7@ufl.edu.
Pediatric Rheumatology Online Journal
|August 22, 2015
Summary
BK virus (BKV), a common polyomavirus, can cause serious kidney issues in transplant patients. This study explores BKV
Area of Science:
- Virology
- Nephrology
- Immunology
Background:
- BK virus (BKV) is a human polyomavirus affecting 60-80% of the population.
- BKV is a known cause of renal failure and complications in transplant recipients.
- The impact of BKV on non-transplanted, immunocompromised individuals, like those with SLE, is less understood.
Purpose of the Study:
- To investigate the clinical significance of BK virus (BKV) in patients with systemic lupus erythematosus (SLE).
- To highlight the potential for BK virus nephropathy (BKVN) in immunocompromised SLE patients.
Main Methods:
- Literature review focusing on clinical manifestations and associations.
- Analysis of case studies and existing research on BKV in immunocompromised populations.
Main Results:
- BKV is prevalent in the general population and causes significant renal complications in transplant patients.
- SLE patients present unique risk factors for BKV infection due to nephritis and immunosuppressive therapy.
- Further research is needed to fully elucidate BKV's role and impact in SLE patients.
Conclusions:
- BK virus (BKV) poses a potential threat to immunocompromised patients, including those with systemic lupus erythematosus (SLE).
- Understanding BKV's clinical aspects in SLE is crucial for managing potential renal complications.
- Early detection and management strategies for BKV in SLE patients warrant further investigation.
