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Engineering Nanomaterials for Biomedical Applications Requires Understanding the Nano-Bio Interface: A Perspective
Jennifer E Gagner1,2,3, Siddhartha Shrivastava1,3, Xi Qian1,2,3
1†Rensselaer Nanotechnology Center, Rensselaer Polytechnic Institute, Troy, New York 12180, United States.
The Journal of Physical Chemistry Letters
|August 22, 2015
Summary
Controlling nanomaterial interfaces is key to overcoming challenges like toxicity and improving efficacy for biomedical applications. Understanding surface chemistry and molecular arrangement enhances nanobiomaterial development for diagnostics and therapeutics.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Nanobiomaterials show great promise for diagnostics and therapeutics.
- Clinical translation of nanomaterial-based therapeutics faces challenges including toxicity, immunogenicity, and reduced efficacy.
- Understanding nanomaterial-biological interactions is crucial for overcoming these hurdles.
Purpose of the Study:
- To explore how controlling the nanomaterial interface can favorably influence interactions with biomolecules.
- To identify strategies for enhancing the biomedical applications of nanobiomaterials.
Main Methods:
- Investigating recent advancements in nanoparticle synthesis and surface chemistry.
- Analyzing the impact of controlled surface chemistry organization on protein adsorption and structure.
- Examining how spatial arrangement of atomic and molecular species at the interface affects biological outcomes.
Main Results:
- Developments in nanoparticle synthesis allow for better control over surface chemistry.
- Understanding the spatial organization of surface chemistry is critical for predicting protein adsorption and biological responses.
- Controlled interfaces can modulate interactions with biomolecules.
Conclusions:
- Tailoring the nanomaterial interface is essential for advancing nanobiomaterials in medicine.
- Controlling surface chemistry and its organization offers a pathway to improved efficacy and safety.
- Further research into interface control can accelerate the clinical application of nanobiomaterials.
