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Primary and secondary haemostasis changes related to aging
Cesar Sepúlveda1, Iván Palomo2, Eduardo Fuentes2
1Department of Clinical Biochemistry and Immunohaematology, Faculty of Health Sciences, Interdisciplinary Excellence Research Program on Healthy Aging (PIEI-ES), Universidad de Talca, Talca, Chile.
Mechanisms of Ageing and Development
|August 23, 2015
Summary
The aging population experiences significant changes in the hemostatic system, leading to an increased risk of thrombosis. Understanding these age-related hemostatic alterations is crucial for geriatric health management.
Area of Science:
- Gerontology
- Hematology
- Physiology
Background:
- Global life expectancy is increasing, leading to a growing elderly population.
- Aging is associated with physiological changes, including alterations in the hemostatic system.
- The hemostatic system's balance shifts towards a pro-thrombotic state in older individuals.
Purpose of the Study:
- To systematically review age-related changes in hemostatic components.
- To elucidate the specific alterations in coagulation, natural anticoagulation, and fibrinolysis during aging.
- To examine changes in platelet activation markers associated with aging.
Main Methods:
- Systematic review of scientific literature.
- Analysis of studies investigating hemostatic factors in aging populations.
- Examination of data on coagulation factors, natural anticoagulants, fibrinolytic system proteins, and platelet activation markers.
Main Results:
- Aging alters levels and activity of coagulation factors, natural anticoagulants, and fibrinolytic proteins.
- The hemostatic balance in elderly individuals shifts towards a pro-thrombotic state.
- Platelet activity indicates abnormal activation in aging, evidenced by markers like P-selectin and beta-thromboglobulin.
Conclusions:
- Aging significantly impacts the hemostatic system, promoting a pro-thrombotic tendency.
- Understanding these age-associated hemostatic changes is vital for developing effective health strategies for the elderly.
- Further research into geriatric hemostasis can inform preventative and therapeutic interventions.
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