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Related Concept Videos

Classification of Epithelial Tissues: Overview01:22

Classification of Epithelial Tissues: Overview

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Epithelial tissues are classified according to the shape of the cells and the number of cell layers formed. Cell shapes can be squamous (flattened and thin), cuboidal (square-like, as wide as it is tall), or columnar (rectangular, taller than it is wide). Additionally, the nucleus shape helps identify the type of epithelial cells. Squamous cells have flattened disc-shaped nuclei, cuboidal cells have spherical nuclei, and columnar cells have elongated nuclei.
Based on the number of cell layers,...
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Tumor Progression02:07

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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Classification of Epithelial Tissues: Glandular Epithelium01:20

Classification of Epithelial Tissues: Glandular Epithelium

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The glandular epithelium is made of one or more epithelial cells modified to synthesize and secrete chemical substances. Glandular epithelia can be classified based on cell number. Unicellular glands have individual secretory cells scattered across the epithelial monolayer. In contrast, multicellular glands consist of a hollow tubular duct attached to the cluster of secretory cells located in the deep pockets.
Multicellular glands are formed during early development when epithelial budding...
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Epithelial Tissues and Their Functions01:23

Epithelial Tissues and Their Functions

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Epithelial tissues are large sheets of cells covering all of the surfaces of the body. These surfaces can be internal or external, for example, skin, airways, the digestive tract, the urinary system, and the reproductive system. Hollow organs and body cavities that do not connect to the body's exterior, including blood vessels and serous membranes, are lined by epithelial tissue known as the endothelium.
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Related Experiment Video

Updated: Apr 5, 2026

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
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Myoepithelial Tumors: An Update.

Vickie Y Jo1

  • 1Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

Surgical Pathology Clinics
|August 23, 2015
PubMed
Summary

Primary myoepithelial neoplasms are rare tumors of soft tissue, skin, and bone. This review details their classification, characteristics, and genetic alterations, distinguishing them from salivary gland tumors.

Area of Science:

  • Oncology
  • Pathology
  • Genetics

Background:

  • Primary myoepithelial neoplasms of soft tissue are uncommon.
  • These tumors share features with salivary gland counterparts but have distinct malignancy criteria.
  • Classification includes mixed tumor/chondroid syringoma, myoepithelioma, and myoepithelial carcinoma.

Purpose of the Study:

  • To review the clinicopathologic and morphologic characteristics of soft tissue myoepithelial neoplasms.
  • To discuss distinct variants and known genetic alterations.
  • To compare diagnostic criteria with salivary gland myoepithelial tumors.

Main Methods:

  • Literature review of clinicopathologic and genetic studies.
  • Analysis of morphological and immunophenotypic features.
Keywords:
BoneCutaneousMixed tumorMyoepithelial carcinomaMyoepitheliomaSoft tissue

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  • Comparison of diagnostic criteria for malignancy.

    • Main Results:

    • Myoepithelial tumors of soft tissue, skin, and bone exhibit diverse morphology and immunophenotypes.
    • Malignancy in soft tissue sites is determined by cytologic atypia, unlike invasive growth in salivary glands.
    • Specific genetic alterations are increasingly identified in these neoplasms.

    Conclusions:

    • Soft tissue myoepithelial neoplasms require careful clinicopathologic and genetic characterization.
    • Understanding distinct features is crucial for accurate diagnosis and classification.
    • Further research into genetic alterations may refine understanding and treatment strategies.