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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

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Types of RNA01:20

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
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Types of RNA01:23

Types of RNA

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
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Ribosome Profiling02:24

Ribosome Profiling

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Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
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Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
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Regulation of Expression at Multiple Steps01:23

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The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

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The specificity of long noncoding RNA expression.

Brian S Gloss1, Marcel E Dinger1

  • 1Division of Genomics and Epigenetics, Garvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, UNSW Australia.

Biochimica Et Biophysica Acta
|August 23, 2015
PubMed
Summary
This summary is machine-generated.

Long noncoding RNAs (lncRNAs) are crucial genomic regulators, with their cell-specific expression initially hindering discovery but now offering potential for biomarkers and targeted therapies.

Keywords:
ExpressionLong noncoding RNATechnologyTranscriptomics

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Area of Science:

  • Genomics and molecular biology
  • Transcriptomics
  • Epigenetics

Background:

  • Long noncoding RNAs (lncRNAs) are a fundamental class of molecules regulating the genome.
  • The discovery of pervasive transcription revealed the dynamic nature of the transcriptome.
  • lncRNA loci are predicted to outnumber messenger RNA (mRNA) loci.

Purpose of the Study:

  • To review the history and evolution of long noncoding RNA research.
  • To highlight the impact of technological advancements on lncRNA discovery.
  • To discuss the significance of lncRNA expression specificity in biological function and therapeutic potential.

Main Methods:

  • Historical review of lncRNA research.
  • Analysis of technological advancements in genomics and transcriptomics.
  • Synthesis of current understanding of lncRNA function and mechanisms.

Main Results:

  • lncRNA research has evolved significantly over the past decade.
  • Technological progress has been crucial for uncovering lncRNAs and their functions.
  • lncRNA expression specificity is key to their roles as biomarkers and therapeutic targets.

Conclusions:

  • lncRNAs are increasingly recognized for their regulatory roles and potential applications.
  • Understanding lncRNA structure-function relationships is essential for deciphering their encoded information.
  • Future research will likely clarify the full scope of lncRNA functions and therapeutic utility.