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Effects of pre-exercise alkalosis on the decrease in VO2 at the end of all-out exercise.

Claire Thomas1,2, Rémi Delfour-Peyrethon3, David J Bishop4

  • 1French National Institute of Sports (INSEP), 11 Tremblay Avenue, 75012, Paris, France. claire.thomas@univ-evry.fr.

European Journal of Applied Physiology
|August 23, 2015
PubMed
Summary

Pre-exercise sodium bicarbonate ingestion prevented a decrease in oxygen uptake (VO2) during intense exercise. This alkalosis also reduced the decline in power output, suggesting improved performance and acid-base balance during supramaximal exercise.

Keywords:
Acid–base statusFatigueHigh-intensity exerciseMinute ventilationOxygen uptakeSodium bicarbonate

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Area of Science:

  • Exercise Physiology
  • Sports Science
  • Biochemistry

Background:

  • Understanding the impact of acid-base balance on exercise performance is crucial for athletes and coaches.
  • Metabolic acidosis during high-intensity exercise can impair oxygen uptake (VO2) and reduce power output.
  • Sodium bicarbonate is a known ergogenic aid that can induce metabolic alkalosis.

Purpose of the Study:

  • To investigate the effects of pre-exercise sodium bicarbonate ingestion on oxygen uptake (VO2) during a supramaximal exercise test (SXT).
  • To determine if alkalosis can mitigate the exercise-induced decrease in VO2 and power output.

Main Methods:

  • Eleven well-trained cyclists performed a 70-second all-out cycling test in a double-blind, placebo-controlled study.
  • Participants ingested either sodium bicarbonate (NaHCO3) or calcium carbonate (PLA) before exercise.
  • Blood samples were analyzed for acid-base balance, and ventilatory parameters were measured during rest and exercise.

Main Results:

  • Placebo ingestion led to mild acidosis and a significant decrease in VO2, correlated with reduced minute ventilation (VE).
  • Pre-exercise alkalosis from sodium bicarbonate significantly attenuated the decrease in VO2 and mean power output.
  • The reduction in VO2 decrease was linked to changes in VE, not power output.

Conclusions:

  • Pre-exercise alkalosis effectively counteracted the VO2 decrease associated with mild acidosis during supramaximal exercise.
  • Changes in ventilatory response and muscle acid-base status likely contributed to the observed performance benefits.
  • Sodium bicarbonate may be a beneficial supplement for improving exercise capacity in high-intensity activities.