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Creatine as a booster for human brain function. How might it work?

Caroline D Rae1, Stefan Bröer2

  • 1Neuroscience Research Australia, Barker St Randwick, NSW 2031, Australia; School of Medical Sciences, UNSW, High Street, Randwick, NSW 2052, Australia.

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Summary
This summary is machine-generated.

Creatine plays vital roles in brain energy supply, mitochondrial function, and neuroprotection. This review explores its translation into human clinical applications and discusses future possibilities.

Keywords:
BioenergeticsCognitionCreatine kinaseNMDA receptorNeuroprotectionPhosphocreatine

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Pharmacology

Background:

  • Creatine is a naturally occurring organic acid in animal tissues.
  • Established roles in the brain include energy buffering, mitochondrial efficiency, antioxidant, and neuroprotection.
  • Much evidence stems from in vitro and pre-clinical studies.

Purpose of the Study:

  • To examine the multifaceted roles of creatine in the brain.
  • To review the current status of translating creatine research into human and clinical use.
  • To discuss potential future applications of creatine in human health.

Main Methods:

  • Literature review of existing research on creatine.
  • Analysis of pre-clinical and in vitro studies.
  • Exploration of clinical trial data and case studies.

Main Results:

  • Creatine demonstrates significant potential in preclinical models for various neurological conditions.
  • Translation to human clinical applications is still in early stages for many proposed uses.
  • Evidence supports creatine's role in energy metabolism and neuroprotection.

Conclusions:

  • Creatine's neuroprotective and bioenergetic properties are well-supported.
  • Further clinical research is needed to establish efficacy and safety for human therapeutic use.
  • Potential applications in neurological disorders and cognitive enhancement warrant continued investigation.