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Toll-like receptor-3 gene polymorphism in patients with Japanese encephalitis

Sumant Biyani1, Ravindra Kumar Garg1, Amita Jain2

  • 1Department of Neurology, King George Medical University, Uttar Pradesh, Lucknow, India.

Journal of Neuroimmunology
|August 24, 2015
PubMed
Abstract

Insights

Genetic variations in Toll-like receptor 3 (TLR3) are linked to increased susceptibility to Japanese encephalitis (JE) in India. However, TLR3 gene polymorphism does not appear to influence mortality rates from the disease.

Area of Science:

  • Immunogenetics
  • Neurovirology
  • Infectious Diseases

Background:

  • Japanese encephalitis (JE) is a severe mosquito-borne viral encephalitis prevalent in India.
  • Toll-like receptors (TLRs) are crucial in the host immune response against flaviviruses.
  • Investigating TLR3's role may reveal genetic factors influencing JE susceptibility.

Purpose of the Study:

  • To determine if Toll-like receptor 3 (TLR3) gene abnormalities increase susceptibility to Japanese encephalitis (JE).
  • To analyze the association between TLR3 Leu412Phe polymorphism and JE risk in the Indian population.

Main Methods:

  • Genotyping of TLR3 Leu412Phe polymorphism using polymerase chain reaction (PCR) and genetic sequencing.
  • Comparison of TLR3 polymorphism frequencies between 103 JE patients and 103 healthy controls from an endemic area.

Main Results:

  • A significantly higher frequency of TLR3 Leu412Phe polymorphism (TT and CT genotypes) was observed in JE patients compared to controls (P=0.013-0.019).
  • The 412Phe allele (T) of the TLR3 gene was significantly more prevalent in JE patients (P=0.001).
  • No significant association was found between TLR3 Leu412Phe polymorphism and mortality within one month of JE diagnosis.

Conclusions:

  • TLR3 gene polymorphism may contribute to host genetic susceptibility to Japanese encephalitis in the Indian population.
  • TLR3 polymorphism does not appear to be a significant factor in JE-related mortality.

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