Primary nephrotic syndrome in Qatar (Arabian Gulf)

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Updated: Jul 27, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
07:35

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Published on: June 23, 2015

E A Eltohami, K F Akl

    The British Journal of Clinical Practice
    |October 1, 1989
    PubMed

    Insights

    Most children with primary nephrotic syndrome respond to steroids initially. However, a significant portion may develop steroid resistance or frequent relapses, necessitating further investigation and tailored treatment strategies.

    Area of Science:

    • Pediatric Nephrology
    • Glomerular Diseases

    Background:

    • Primary nephrotic syndrome is a significant kidney disorder in children.
    • Steroid responsiveness is a key prognostic indicator.

    Purpose of the Study:

    • To analyze the clinical course and renal biopsy findings in children with primary nephrotic syndrome.
    • To identify patterns of steroid resistance and frequent relapses.

    Main Methods:

    • Retrospective study of 62 children diagnosed with primary nephrotic syndrome.
    • Analysis of initial steroid response, relapse frequency, and development of steroid resistance.
    • Review of renal biopsy results for steroid-resistant and relapsing cases.

    Main Results:

    • 88.7% of children were initially steroid sensitive; 11.2% were steroid resistant.
    • Among steroid-sensitive cases, 21.8% experienced frequent relapses.
    • Renal biopsies revealed focal glomerulosclerosis, minimal change disease, and membranoproliferative glomerulonephritis in various subgroups.

    Conclusions:

    • While many children achieve initial remission, a notable percentage develop steroid resistance or frequent relapses.
    • Renal biopsy findings vary among different clinical presentations of nephrotic syndrome.
    • Long-term management strategies should account for the potential for treatment resistance and relapse.

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