Related Experiment Video

Updated: Apr 5, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

511

Therapeutic Use of MicroRNAs in Cancer

Alessandra Tessitore1, Germana Cicciarelli, Valentina Mastroiaco

  • 1Dept. of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio, Coppito II, L'Aquila, Italy. alessandra.tessitore@univaq.it.

Anti-Cancer Agents in Medicinal Chemistry
|August 25, 2015
PubMed

Insights

MicroRNAs (miRNAs) regulate gene expression and are implicated in cancer. This review explores their therapeutic potential and role in predicting treatment response for solid tumors.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression.
  • Aberrant miRNA expression is linked to cancer initiation, development, and progression.
  • miRNAs are emerging as therapeutic targets and biomarkers for cancer therapy response.

Purpose of the Study:

  • To review the role of miRNAs in cancer.
  • To discuss miRNAs as therapeutic agents.
  • To examine miRNA involvement in modulating response to chemo/radio/targeted therapy.

Main Methods:

  • Literature review of studies on miRNA function in cancer.
  • Analysis of miRNA-based therapeutic strategies in pre-clinical models.
  • Discussion of challenges in clinical translation of miRNA therapy.

Main Results:

  • miRNA dysregulation is a key factor in cancer pathogenesis.
  • Restoring or repressing miRNA activity shows promise for cancer management.
  • miRNAs can influence patient response to various cancer treatments.

Conclusions:

  • miRNA-based therapies hold significant potential for cancer treatment.
  • Further research is needed to overcome delivery and safety challenges for clinical application.
  • miRNAs are valuable for predicting and modulating treatment efficacy in solid tumors.

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