Schizophrenia Research: A Progress Report

This overview highlights the current hot topics in schizophrenia research. One major drawback to progress is the ability to define and focus on the right patient group. Schizophrenia is a biased and heterogeneous (group of) condition(s), the boundaries of which remain uncertain. An initiative that will focus attention away from (mere) symptoms of the illness and toward its underlying neurobiological construct(s) is the Research Domain Criteria. A preliminary analysis from a large neurobiological study suggests that 3 distinct biological phenotypes underlie the clinical expression of 1 major psychosis. A firmer neurobiologically based foundation is needed to advance this field.