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Related Concept Videos

Development of Human Microbiota01:30

Development of Human Microbiota

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The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
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Introduction to the Human Microbiota01:22

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Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity,...
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Microbiota of the Urogenital Tract01:28

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The human urogenital system, once thought to be sterile in healthy individuals, is now recognized as a complex microbial habitat. Advancements in molecular sequencing techniques have revealed that even in healthy adults, the kidneys and bladder harbor microbial populations similar to those found in the distal urethra, albeit in much lower abundance. These resident microorganisms, while generally innocuous, can become opportunistic pathogens under conditions that alter the urogenital...
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Functions of the Gut Microbiota01:18

Functions of the Gut Microbiota

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The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
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Factors Affecting the Risk of Infection01:26

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
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Microbiota of the Large Intestine01:27

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The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...
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Frailty Assessment in an Aging Mouse Model
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Frailty and the Microbiome.

Conor J Meehan1, Morgan G I Langille, Robert G Beiko

  • 1Faculty of Computer Science, Dalhousie University, Halifax, N.S., Canada.

Interdisciplinary Topics in Gerontology and Geriatrics
|August 25, 2015
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Summary
This summary is machine-generated.

The human microbiome, a diverse community of microbes, plays a vital role in health. Research is exploring the link between the microbiome and frailty, a condition often associated with aging.

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Area of Science:

  • Microbiology
  • Gerontology
  • Human Health

Background:

  • The human body hosts a diverse microbiome, crucial for symbiotic associations.
  • Microbiome disruption is linked to various diseases due to breakdowns in nutrition, signaling, and immune defense.
  • Microbial composition changes with aging, influenced by diet and living conditions.

Purpose of the Study:

  • To explore the largely uninvestigated link between the human microbiome and frailty.
  • To determine if distinct microbial signatures are associated with frailty.
  • To assess the potential diagnostic and therapeutic utility of such microbial signatures.

Main Methods:

  • This study focuses on the relationship between the microbiome and frailty.
  • Further research is needed to establish causality and identify specific microbial signatures.
  • Investigating the influence of aging, diet, and environment on the microbiome's role in frailty.

Main Results:

  • The link between the microbiome and frailty remains largely unexplored.
  • The microbiome is hypothesized to influence health factors contributing to frailty.
  • Further research is required to confirm these associations and their implications.

Conclusions:

  • The microbiome's role in aging and frailty requires further investigation.
  • Identifying frailty-associated microbial signatures could offer new diagnostic and therapeutic avenues.
  • Understanding the microbiome's impact on health is crucial, especially in older adults.