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Revised reference values for selenium intake.

A P Kipp1, D Strohm2, R Brigelius-Flohé1

  • 1German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Arthur-Scheunert-Allee 114-116, D-14558 Nuthetal, Germany.

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
|August 26, 2015
PubMed
Summary
This summary is machine-generated.

New reference values for selenium intake were established using selenoprotein P (SePP) saturation. These updated guidelines provide daily selenium intake recommendations for adults, children, and infants, considering factors like body weight and lactation.

Keywords:
Dietary reference valueHuman nutritionNutrient intakeSelenium

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Area of Science:

  • Nutrition Science
  • Biochemistry
  • Public Health

Background:

  • The German, Austrian, and Swiss nutrition societies jointly publish reference values for nutrient intake.
  • Selenium is an essential trace element crucial for various physiological functions.
  • Previous selenium intake recommendations required revision based on updated scientific criteria.

Purpose of the Study:

  • To revise and establish updated reference values for selenium intake in Germany, Austria, and Switzerland.
  • To define selenium intake requirements across different age groups and physiological states.
  • To ensure adequate selenium nutrition and prevent deficiency.

Main Methods:

  • Utilized plasma selenoprotein P (SePP) saturation as the primary criterion for deriving selenium intake reference values in adults.
  • Established baseline intake for selenium-deficient populations (e.g., China) to determine saturation levels.
  • Extrapolated selenium requirements for children and adolescents based on adult values and body weight ratios.
  • Calculated specific recommendations for infants based on breast milk intake and body weight.
  • Adjusted recommendations for lactating and pregnant women based on physiological needs and selenium transfer via breast milk.

Main Results:

  • SePP saturation in adults from selenium-deficient regions was achieved at a daily intake of 49μg.
  • Recommended daily selenium intake values for adults were set at 70μg for men and 60μg for women.
  • Estimated daily selenium intake values for infants were 10μg (0-4 months) and 15μg (4-12 months).
  • A higher reference value of 75μg/day was indicated for lactating women.
  • No increased reference value was deemed necessary for pregnant women.

Conclusions:

  • The revised reference values for selenium intake provide updated guidance for ensuring adequate selenium status in the population.
  • Plasma SePP saturation is a reliable biomarker for assessing selenium nutritional status and deriving intake recommendations.
  • Specific recommendations cater to diverse physiological needs, including different age groups and lactation.