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The scotopic threshold response in diabetic retinopathy
1Department of Ophthalmology, Sydney Eye Hospital, Woolloomooloo, NSW, Australia.
Eye (London, England)
|January 1, 1989
Summary
The scotopic threshold response (STR) shows a strong correlation with diabetic retinopathy severity. This electroretinogram component may aid in assessing diabetic eye disease.
Area of Science:
- Ophthalmology
- Neuroscience
- Medical Imaging
Background:
- The scotopic threshold response (STR) is a recently identified electroretinogram component.
- It originates in the inner retina and is elicited by dim stimuli in dark-adapted eyes.
Purpose of the Study:
- To investigate the correlation between STR characteristics and diabetic retinopathy (DR) severity.
- To evaluate the potential of STR as a diagnostic tool for DR.
Main Methods:
- STR, scotopic b-wave, oscillatory potentials (OPs), and pattern electroretinogram (PERG) were recorded in 50 diabetic patients.
- Diabetic retinopathy was graded using stereo color fundus photographs and fluorescein angiography.
Main Results:
- Significant correlations were found between STR amplitude/latency and DR severity.
- Similar correlations were observed for OPs, with weaker links to PERG amplitude.
- No significant correlation was found between PERG latency and DR severity.
Conclusions:
- Results support an inner retinal origin for the STR.
- STR shows promise for electroretinographic assessment of diabetic retinopathy.